Sometime around 6000 BCE a nomadic herding people settled into villages in the Mountainous region just west of the Indus River. There they grew barley and wheat using sickles with flint blades, and they lived in small houses built with adobe bricks. After 5000 BCE the climate in their region changed, bringing more rainfall, and apparently they were able to grow more food, for they grew in population. They began domesticating sheep, goats and cows and then water buffalo. Then after 4000 BCE they began to trade beads and shells with distant areas in central Asia and areas west of the Khyber Pass. And they began using bronze and working metals.

The climate changed again, bringing still more rainfall, and on the nearby plains, through which ran the Indus River, grew jungles inhabited by crocodiles, rhinoceros, tigers, buffalo and elephants. By around 2600 BCE, a civilization as grand as that in Mesopotamia and Egypt had begun on the Indus Plain and surrounding areas. By 2300 BCE this civilization had reached maturity and was trading with Mesopotamia. Seventy or more cities had been built, some of them upon buried old towns. There were cities from the foothills of the Himalayan Mountains to Malwan in the south. There was the city of Alamgirpur in the east and Sutkagen Dor by the Arabian Sea in the west.

One of these cities was Mohenjo-daro (Mohenjodaro), on the Indus river some 250 miles north of the Arabian Sea, and another city was Harappa, 350 miles to the north on a tributary river, the Ravi. Each of these two cities had populations as high as around 40,000. Each was constructed with manufactured, standardized, baked bricks. Shops lined the main streets of Mohenjo-daro and Harappa, and each city had a grand marketplace. Some houses were spacious and with a large enclosed yard. Each house was connected to a covered drainage system that was more sanitary than what had been created in West Asia. And Mohenjo-daro had a building with an underground furnace (a hypocaust) and dressing rooms, suggesting bathing was done in heated pools, as in modern day Hindu temples.

The people of Mohenjo-daro and Harappa shared a sophisticated system of weights and measures, using an arithmetic with decimals. Whether these written symbols were a part of a full-blown written language is a matter of controversy among scholars, some scholars pointing out that this and the brevity of grave site inscriptions and symbols on ritual objects are not evidence of a fully developed written language.

The people of Mohenjo-daro and Harappa mass-produced pottery with fine geometric designs as decoration, and they made figurines sensitively depicting their attitudes. They grew wheat, rice, mustard and sesame seeds, dates and cotton. And they had dogs, cats, camels, sheep, pigs, goats, water buffaloes, elephants and chickens.

Tyrannosaurus rex was one of the largest land carnivores of all time; the largest complete specimen, FMNH PR2081 ("Sue"), measured 12.8 metres (42 ft) long, and was 4.0 metres (13 ft) tall at the hips. Mass estimates have varied widely over the years, from more than 7.2 metric tons (7.9 short tons), to less than 4.5 metric tons (5.0 short tons), with most modern estimates ranging between 5.4 and 6.8 metric tons (6.0 and 7.5 short tons). Although Tyrannosaurus rex was larger than the well known Jurassic theropod Allosaurus, it was slightly smaller than Cretaceous carnivores Spinosaurus and Giganotosaurus.

The neck of T. rex formed a natural S-shaped curve like that of other theropods, but was short and muscular to support the massive head. The forelimbs had only two clawed fingers, along with an additional small metacarpal representing the remnant of a third digit. In contrast the hind limbs were among the longest in proportion to body size of any theropod. The tail was heavy and long, sometimes containing over forty vertebrae, in order to balance the massive head and torso. To compensate for the immense bulk of the animal, many bones throughout the skeleton were hollow, reducing its weight without significant loss of strength.

The largest known T. rex skulls measure up to 5 feet (1.5 m) in length. Large fenestrae (openings) in the skull reduced weight and provided areas for muscle attachment, as in all carnivorous theropods. But in other respects Tyrannosaurus’ skull was significantly different from those of large non-tyrannosauroid theropods. It was extremely wide at the rear but had a narrow snout, allowing unusually good binocular vision. The skull bones were massive and the nasals and some other bones were fused, preventing movement between them; but many were pneumatized (contained a "honeycomb" of tiny air spaces) which may have made the bones more flexible as well as lighter. These and other skull-strengthening features are part of the tyrannosaurid trend towards an increasingly powerful bite, which easily surpassed that of all non-tyrannosaurids.The tip of the upper jaw was U-shaped (most non-tyrannosauroid carnivores had V-shaped upper jaws), which increased the amount of tissue and bone a tyrannosaur could rip out with one bite, although it also increased the stresses on the front teeth.

The teeth of T. rex displayed marked heterodonty (differences in shape). The premaxillary teeth at the front of the upper jaw were closely packed, D-shaped in cross-section, had reinforcing ridges on the rear surface, were incisiform (their tips were chisel-like blades) and curved backwards. The D-shaped cross-section, reinforcing ridges and backwards curve reduced the risk that the teeth would snap when Tyrannosaurus bit and pulled. The remaining teeth were robust, like "lethal bananas" rather than daggers; more widely spaced and also had reinforcing ridges.Those in the upper jaw were larger than those in all but the rear of the lower jaw. The largest found so far is estimated to have been 30 centimetres (12 in) long including the root when the animal was alive, making it the largest tooth of any carnivorous dinosaur.